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Abstract

A new spectrophotometric method for the estimation of primaquine using MBTH

Author(s): BS Sastry, EV Rao, MK Tumuru, C SP Sastry
Dept. of Pharmaceutical Sciences and Foods and Drugs Laboratory, Dept. of Chemistry, Andhra University, Waltair 530 003

Correspondence Address:
B S Sastry Dept. of Pharmaceutical Sciences and Foods and Drugs Laboratory, Dept. of Chemistry, Andhra University, Waltair 530 003

A spectrophotometric method for the determination of primaquine at 510 nm, based on its reaction with 3-methyl-2-benzothiazolinone hydrazone (MBTH) in the presence of cerium (IV) to form a stable, pink coloured oxidative coupling product, is reported. The method is applicable in the presence of other antimalarial drugs and to pharmaceutical preparation