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Abstract

A Note On Testing The Equality Of Areas Under The Curve When Using Destructive Measurement Technique In Animal Pharmacokinetics

Author(s): Shubha Rani

Area under the curve (AUC) of concentration versus time is considered in many toxicological, pharmacological and medical investigations. In case that only one measurement for each experimental unit has been recorded, Bailer developed a method for estimating and comparing AUCs with only one sample per experimental unit but with multiple experimental units at each of several time points post dose. In this paper, a modification of Bailer’s1 method is reported to account for estimation of the variance for small sample sizes.