A QSAR Study On The Antileishmanial Activity Of Some Substituted Pyrimidines And Pyrazolo [1,5-a] Pyrimidines
A quantitative structure activity relationship (QSAR) study was made on the antileishmanial activity of substituted pyrimidine, and pyrazolo [1,5-a] pyrimidine analogues using physicochemical and steric descriptors of the varying substituents. The study of pyrimidine analogues indicated the necessity of having unsubstitued pyramidine N(3) for Antileishmanial activity. Also, the C(2) substituent, which is adjacent to N(3), of pyrimidine imporsed steric restrictions for a compound to become leishmanicide. In case of pyrazolo [1,5-a] pyrimidine analogues, the study suggested the role of hydrophobicity and polarity of substituents on antileishmanial activity.