Adsorption Of Acidic And Basic Drugs By Cereal Brans
Studies on the adsorption of three acidic and three basic drugs on wheat bran and rice bran have been reported. Rice bran was found to be a better adsorbent than wheat bran. Basic drugs were adsorbed to a much larger extent compare to acidic drugs. Amongst acidic drugs adsorption of paracetamol was highest. Amongst basic drugs adsorption of promethazine was lowest. Data obeyed Freundlich adsorption isotherm. Acid/base treatment increased the adsorption capacity of bran but the increase was more for wheat bran than rice bran. The possible application of adsorption data in pharmacy has been explored. For the basic antipsychotic drugs, rice bran was found to be a good adsorbent and thus can be effectively used as a safe antidote with no side effects.