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Abstract

An extractive colorimetric method for the determination of ketoconazole from pharmaceutical preparations.

Author(s): RT Sane, RV Tendolkar, DP Gangal, KD Ladage, RM Kothurkar
S.P. Mandali's TDM Laboratory, Scheme 6, Road No. 15, Sion-Koliwada, Sion (E), Bombay-22,

Correspondence Address:
R T Sane S.P. Mandali's TDM Laboratory, Scheme 6, Road No. 15, Sion-Koliwada, Sion (E), Bombay-22

An extractive colorimetric method for the determination of ketoconazole from pharmaceutical preparations is described. The method is based on the formation of ion-pair complexes of the drug with reagents like bromocresol green (BCG), bromocresol purple (BCP) < bromophenol blue (BPB) and bromophenol red (BPR) in acidic medium. The ion-pair compexes formed are quantitatively extracted in chloroform. The method is statistically validated and is found to be precise and accurate.