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Abstract

An Improved Gas Chromatographic Assay Method For HMG-CoA Reductase And Mevalonic Acid

Author(s): P Bharathi Dhasan, R Sundaram, R Suresh Kumar, S. K Mitra, Kala S Kulkarni

A simple and accurate gas chromatographic method for the in vitro estimation of mevalonic acid (as mevalonolactone) was developed. The method showed good sensitivity, accuracy and linearity over a wide concentration range. Detection at lower concentrations without the use of any radioactivity measurements, and more rapid analysis than other existing methods, are the advantages of this modified method.