An overview of curcumin in neurological disorders
1 Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India 2 Department of Neurobiology, University of California Davis Medical Center, Sacramento California, 95817, India
S K Kulkarni Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014 India E-mail: [email protected]
Curcumin, the principal curcuminoid found in spice turmeric, has recently been studied for its active role in the treatment of various central nervous system disorders. Curcumin demonstrates neuroprotective action in Alzheimer's disease, tardive dyskinesia, major depression, epilepsy, and other related neurodegenerative and neuropsychiatric disorders. The mechanism of its neuroprotective action is not completely understood. However, it has been hypothesized to act majorly through its anti-inflammatory and antioxidant properties. Also, it is a potent inhibitor of reactive astrocyte expression and thus prevents cell death. Curcumin also modulates various neurotransmitter levels in the brain. The present review attempts to discuss some of the potential protective role of curcumin in animal models of major depression, tardive dyskinesia and diabetic neuropathy. These studies call for well planned clinical studies on curcumin for its potential use in neurological disorders.