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Abstract

Analgesic, Antiinflammatory And Antibacterial Activity Of Some Novel 2-Phenyl-3- (Substituted Methyl Amino) Quinazolin-4 (3H)-Ones

Author(s): V Alagarsamy, S Revathi, R Kalaiselvi, S Phuvaneshwari, R Revathi, S Amuthalakshmi, S Vijayakumar, S.M Sivakumar, T Angayarkanni, M Sarathadevi, S Saravanakumar, A Thangathiruppathy, R Venkatnarayanan, R Venkatesaperumal

In view of the potent analgesic antiinflammatory and antimicrobial activities exhibited by quinazolin- 4(3H)-ones, a series of novel 2-phenyl-3-(substitutedmethyl amino) quinazolin-4(3H)-ones have been synthesized. When these compounds were evaluated for analgesic, antiinflammatory and antibacterial activities, compounds I and II exhibited comparable analgesic activity, while the compounds II and Ill exhibited comparable antiinflammatory activity with the standard diclofenac sodium.