Analgesic, Antipyretic And Antiulcerogenic Effects Of Andrographolide
Andrographolide from Andrographis panicultata (30, 100, and 300 mg/kg, oral) has been studied for its analgesic, antipyretic and antiulcerogenic activities. Andrographolide did not show any analgesic activity in hot plate test in mice while it showed significant (P< 0.05) analgesic activity in acetic acid-induced writhing in mice and Randall Selitto's test in rats at 300 mg/kg dose. Andrographolide, (100 and 300 mg/kg, oral) produced significant (P < 0.05) antipyretic effect after 3h of administration in Brewer's yeast-induced pyrexia in rats. Andrographolide also possessed significant (p < 0.05) anti-ulcerogenic activity at 100 and 300 mg/kg doses, aspirin induced ulceration in rats.