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Abstract

Analysis Of Roxatidine Acetate Hydrochloride In Bulk And From Sustained Release Formulations

Author(s): S. J Rajput, P. D Trivedi

Two spectrophotometric methods for the estimation of roxatidine acetate hydrochloride (RAH) in bulk drug and in its sustained release tablets have been developed. The method I is based on the formation of a yellow coloured ion pair with bromophenol blue whereas the method II is based on the reaction of RAH with hydroxylamine hydrochloride to get a hydroxamic acid which on further reaction with ferric chloride gives a reddish brown complex. Beer's law was followed in the concentration range of 2 to 15 μg/ml in method I and 50 to 300 μg/ml in method II.