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Abstract

Antiallergic Activity Of Andrographolide

Author(s): S Madav, H. C Tripathi, S. K Tandan, Dinesh Kumar, J Lal

Andrographolide, a diterpene lactone, isolated from Andrographis paniculata significantly decreased degranulation of mast cells of rats and reduced the liberation of histamine from the cells when tested in vitro at concentration of 30, 100 and 300 mg/ml. Moreover, andrographolide was found to produce an increase in delayed hypersensitivity in mice.