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Abstract

Antidepressants fail to adenosine-induced relaxation of the rat caecum

Author(s): AK Mehta, SK Kulkarni
Pharmacology Divn., Dept. of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014

Correspondence Address:
A K Mehta Pharmacology Divn., Dept. of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014

Adenosine induced a concenration-dependent relaxation of the rat caecum preparation. Imipramine, trimipramine, desipramine, tranylcypromine and amitriptyline in a concentration of 20 mu M neither exhibited any effect per se nor modified adenosine-induced relaxation of the rat caecum preparation. These observations suggested that antidepressants do not cause a functionally important inhibition of adenosine uptake, and the reported interactions of antidepressants with adenosine in in vitro may be pharmacologically irrelevent.