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Abstract

Antidiabetic activity of clerodendron phlomoidis leaf extract in alloxan-induced diabetic rats

Author(s): SP Dhanabal, MK Mohan Marugaraja, B Suresh
Department of Phytopharmacy and Phytomedicine (TIFAC CORE), JSS College of Pharmacy, Rocklands, Ootacamund-643 001, India

Correspondence Address:
S P Dhanabal Department of Phytopharmacy and Phytomedicine (TIFAC CORE), JSS College of Pharmacy, Rocklands, Ootacamund-643 001 India E-mail: [email protected]


Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz., 100 and 200 mg/kg. The ethanol extract at 200 mg/kg dose level exhibited significant ( p <0.05) hypoglycemic activity and also correction of altered biochemical parameters viz., cholesterol and triglycerides ( p <0.05).



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