Antidiarrhoeal activity of leaves of Melastoma malabathricum linn
School of Pharmacy, Masterskill University College Health Sciences, G-8, Jalan Kemacahaya 11, Taman Kemacahaya, Batu-9, Cheras 43200, Selangor, Malaysia
JAJ Sunilson School of Pharmacy, Masterskill University College Health Sciences, G-8, Jalan Kemacahaya 11, Taman Kemacahaya, Batu-9, Cheras 43200, Selangor Malaysia [email protected]
The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.