Antifertility efficacy of the plant Balanites roxburghii (balanitaceae) in female rats

Author(s): B Padmashali1, VP Vaidya1, HM Vagdevi1, ND Satyanarayana2
1 Department of Chemistry, Kuvempu University, Shankaraghatta-577 451, India 2 Department of Chemistry, Pharmaceutical Chemistry Division, Gulbarga University, Gulbarga-585 106, India

Correspondence Address:
V P Vaidya Department of Chemistry, Kuvempu University, Shankaraghatta-577 451 India E-mail: [email protected]

Petroleum ether, chloroform, ethanol, and distilled water extracts of the fruits of the plant Balanites Roxburghii (Balanitaceae) were tested for antifertility activity in female albino rats at a dose of 300 and 600 mg/kg body weight orally. Among these, the ethanol extract was found to be most effective in causing significant abortifacient activity. The antifertility activity was found to be dose dependent and reversible on withdrawal of the treatment. Phytochemical screening of the ethanol extract showed positive tests for the presence of alkaloids, glycosides, saponins, flavones, and phenolic compounds. The histological studies of the uterus and ovary were carried out to confirm the estrogenic activity. Acute toxicity studies of the crude extracts in mice revealed the non-toxic nature of the crude extracts.

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