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Abstract

Antifungal activity of Millingtonia hortensis

Author(s): M Sharma1, S Puri2, PD Sharma1
1 University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh - 160 014, India 2 Department of Biotechnology, Punjabi University, Patiala - 140 071, India

Correspondence Address:
P D Sharma University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh - 160 014 India E-mail: [email protected]


Antifungal activities of different extracts of Millingtonia hortensis were investigated against various fungal pathogens. Methanol extract was found to have stronger activity than fluconazole against yeast like fungi: 4 fold against Candida krusei with 4 µg/ml minimal inhibitory concentration and 2 fold (MIC- 2 µg/ml) against Sacharomyces cerevisiae , though it showed the same activity as fluconazole against Candida glabrata . Aqueous extract also exhibited 4 fold stronger activity against Candida krusei (MIC- 4 µg/ml) and 4 fold (MIC; 2 µg/ml) against Sacharomyces cerevisiae . Chloroform and ethyl acetate extract showed lower activities against all fungal pathogens except for Candida krusei, compared with the standard. Against the filamentous fungus, Trichosporon cutaneum , all extracts showed less activity than the standard.



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