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Abstract

Anti-inflammatory activity and skin retention profiles of topically applied diclofenac gels.

Author(s): J.S.S. College of Pharmacy, Mysore and College of Pharmaceutical Sciences, K.M.C., Manipal. 576 119
C Jayanthi J.S.S. College of Pharmacy, Mysore and College of Pharmaceutical Sciences, K.M.C., Manipal. 576 119

Topical non-steroidal anti-inflammatory formulations are designed to deliver therapeutic levels of the active ingredient to the inflammed tissues without elevating serum levels after application on the skin. This route is an attractive alternative to the oral administration of NSAIDS, which is associated with high incidence of GIT complications and other systemic toxiceffects 1-3. Several brands of anti-inflammatory topical preparations including diclofenac gels are now available in the Indian market.