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Abstract

Antiinflammatory Activity Of The Leaves Of Nothapodytes Foetida, Miers

Author(s): E Sheeja, E Edwin, S. P Dhanbal, B Suresh

To study the antiinflammatory activity of Nothapodytes foetida, Miers using Wistar rats of either sex, the leaves of Nothapodytes foetida were extracted using petroleum ether and then with ethanol for 72 h each. Both the extracts were in 3 dose levels of 50 mg/kg, 100 mg/kg and 200 mg/kg. Antiinflammatory activity of the extracts was studied by carrageenan-induced hind paw edema in rats and the paw measured plethysmometrically at 0,2 and 4 h after injection. The activities of the extracts were compared with control and standard, ibuprofen. All the drugs were administered orally. When compared to the petroleum ether extract the antiinflammatory activity of ethanolic extract was found to be effective and 200 mg/kg dose of ethanolic extract significantly (P<0.01) reduced the inflammation, which was comparable with that of the standard, ibuprofen.