Antioxidant and hypoglycemic activities of exopolysaccharide by submerged culture of inocutus hispidus
1Technical center of China Tobacco Guangxi Industrial Co. Ltd., Nanning-530 001, China 2College of Food and Biological Engineering, Zhengzhou University of Light Industry, Henan-450 002, China 3Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
C P Xu College of Food and Biological Engineering, Zhengzhou University of Light Industry, Henan-450 002 China E-mail: [email protected]
This work was to investigate the hypoglycemic and antioxidant activities of the exopolysaccharides produced in a stirred-tank bioreactor by Inocutus hispidus. The exopolysaccharides showed significant antioxidant activities, up to 70.7±2.5% inhibition of hydroxyl radicals, 50% inhibition of 2,2-diphenyl-1-picrylhydrazyl radicals, and a Trolox equivalent antioxidant capacity of 3.3 mM. The exopolysaccharide also showed notable hypoglycemic effects in streptozotocin-induced diabetic mice, reducing the plasma glucose, total cholesterol and triacylglycerol concentrations by 18.2±1.5, 20.9±0.8 and 14.4±0.4, respectively. The results demonstrated the potential of this EPS for human health protection against oxidative damage and hyperglycemia.