Application of simplex analysis for development of dispersible tablets of cyproheptadine hydrochloride.
L.M. College of Pharmacy, Navrangpura, Ahmedabad 380 009
M C Gohel L.M. College of Pharmacy, Navrangpura, Ahmedabad 380 009
Dispersible tablets of cyproheptadine-HCI were prepared according to three component simplex optimization technique. Disintegration time of seven batches of the tablets in distilled water was determined. A polynomial equation for computing disintegration time based on simplex design is generated. The application of the equation is demonstrated for predicting disintegration time for a extra-design check point. A contour plot of the results based on the experiment is also presented.