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Abstract

Application of simplex analysis for development of dispersible tablets of cyproheptadine hydrochloride.

Author(s): MC Gohel, M RG Shah, S RM Patel, KB Gandhi
L.M. College of Pharmacy, Navrangpura, Ahmedabad 380 009

Correspondence Address:
M C Gohel L.M. College of Pharmacy, Navrangpura, Ahmedabad 380 009

Dispersible tablets of cyproheptadine-HCI were prepared according to three component simplex optimization technique. Disintegration time of seven batches of the tablets in distilled water was determined. A polynomial equation for computing disintegration time based on simplex design is generated. The application of the equation is demonstrated for predicting disintegration time for a extra-design check point. A contour plot of the results based on the experiment is also presented.