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Abstract

Assay Of Lacidipine In Tablets By Extraction Spectrophotometry

Author(s): G Vidya Sagar, N. V. S Gangadhara Rao, B. S Sastry

Three simple spectrophotometric methods for the analysis of lacidipine in pure form or in tablets have been developed based on the formation of chloroform soluble ion associates under specific experimental conditions. Three acidic dyes, tropaeolin 000 (method A), bromocresol green (method B) and azocarmine G (method C) were utilized. The extracts of ion associates exhibited absorption maxima at 420, 500 and 540 nm for methods A, B and C, respectively. Good agreement with Beer's law was found in the range of 10-60 μg/ml (method A), 10-60 μg/ml (method B) and 10-70 μg/ml (method C). These methods are simple, precise and accurate with excellent recovery of 98-102% and also do not require any separation of soluble excipients in tablets. The results obtained are reproducible with coefficient of variation of less than 1.0%.