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Abstract

Biological Activities Of Sulfonamides

Author(s): M. A Bhat, M Imran, S. A Khan, N Siddiqui

Sulfonamides exhibit broad range of biological activities. Several sulfonamides are used in therapy such as celecoxib, nimesulide, delavirdine, acetazolamide, methazolamide, furosemide, ethoxzolamide, dichlorphenamide, dorzolamide, brinzolamide, sulpiride, sotalol, tolbutamide, chlorpropamide, tolazamide, acetohexamide, glipizide, gliburide, glymidine, zonisamide, thiothixene and famotidine. So far, modifications of the sulfonamides have proven highly effective and modifications that have been made so far do not exhaust the possible changes that can be made to improve potency and efficacy of these sulfonamides. The present review highlights the recently synthesized sulfonamides possessing important potential biological activities. It would be interesting to see whether new sulphonamide derivatives can be utilized as potent therapeutic agents in future.