Biological assay and antimitotic activity of novel analogues of ?-apopicropodophyllin
Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, India
Y B Basavaraju Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570 006 India E-mail: [email protected]
Antimitotic activity of new synthetic analogues benzyl (4), cyclohexyl (5) and 1,4-ethylenedioxy cyclohexyl (6) of β-apopicropodophyllin has been determined by onion root tip method. Analogues 4,5 and 6 synthesised in the present work showed strong to moderate antimitotic activity. They might bind to the critical cells either through hydrophobic forces or acylation is not clearly known but inhibits mitosis in the critical cells.