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Abstract

Blood Brain Barrier : Smuggling Past The Barricades

Author(s): V Chivukula, M. T Chhabria

Getting onto the other side of the blood brain barrier presents the most formidable obstacle for agents intended to treat central nervous system disorders like Alzheimer's disease, Huntington's chorea, Schizophrenia, Parkinsonism and multiple sclerosis. The blood brain barrier impedes drug delivery at potential target sites. Current strategies to aid drug delivery to the central nervous system are lipidisation, chemical modification and molecular antibody technology. The future directs towards development of strategies that harness receptors, vesicles and viral genes to deliver therapeutic agents to the central nervous system.