Chemoprotective Action Of Septilin Against Cyclophosphamide Toxicity
Oral administration of septilin was found to protect mice from cyclophosphamide-induced leukopenia. Total leukocyte counts in Septilin treated animals on day 12 were 2400 cells/mm3 which was significantly higher (p < 0.005) compared to controls (700 cells/mm3) and reached the base line value on day 16 (12,000 cells/ mm3. The bone marrow cellularity was also significantly higher compared to controls. There was no change in the hemoglobin levels in spectilin treated animals. Moreover, Septilin treatment prevented the loss of body weight and reduced the mortality in mice treated with cyclophosphamide. This indicates the usefulness of Septilin in chemotherapy-induced leukopenia.