All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Colorimetric estimation of sulphacetamide sodium in bulk and in formulations

Author(s): Ajay Gaur, RK Gupta, B Shrivastava
L. B. S. College of Pharmacy, Tilak Nagar, Jaipur, Rajasthan - 302004, India

Correspondence Address:
Ajay Gaur L. B. S. College of Pharmacy, Tilak Nagar, Jaipur, Rajasthan - 302004 India E-mail: [email protected]


A new simple and sensitive colorimetric method has been developed for estimation of sulphacetamide sodium in bulk and in pharmaceutical formulations. The method is based on the formation of a yellow colored azo dye by diazotization of sulphacetamide sodium, followed by a diazo-coupling reaction between the resulting product and acetyl acetone. The azo dye exhibited maximum absorbance at 420 nm with apparent molar absorptivity 7.8983 x 10 3 l mol -1 cm -1 . Beer's law was found to be obeyed in the concentration range of 2-20 mg/ml. Results of the analysis were validated statistically and by recovery studies.



Share this