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Abstract

Combinatorial Technology : An Overview

Author(s): A. K Galande

The concept behind combinatorial chemistry burgeoned in the early 1980s when Mario Geysen, invented the method of simultaneous synthesis of diversified peptides. And now the approach has developed so much that combinatorial chemistry is being heralded as a future of pharmaceutical research. For the preliminary cognizance of this exciting technology, I have described techniques involved in combinatorial technology, which will briefly encompass the methodology of combinatorial technology as a tool for drug discovery. Emphasis is on the aspects of library design, syntheses involved, screening, and enumeration procedures which are an integral part of overall methodology. Article also tries to present pros and cons of combinatorial technology and emphasis is on the limitations and disadvantages for adopting combinatorial technology as a developing approach for drug discovery.