Comparison Between Hydroxypropyl b-Cyclodextrin And Polyvinylpyrrolidone As Carriers For Carbamazepine Solid Despersions
Solid dispersions of carbamazepine were prepared in order to improve its aqueous solubility by simple kneading procedure. Hydroxypropyl b-cyclodextrin and polyvinyl pyrrolidone were used as carriers. Solid dispersions were stored at room temperature in a dessicator over anhydrous calcium chloride for one month. The changes in dispersions during storage were assessed by X-ray diffraction studies and dissolution studies. It was concluded from this study that hydroxypropyl b-cyclodextrin, as a carrier, reduced crystalline nature of carbamazepine in solid dispersions to a greater extent than polyvinyl pyrrolidone as a carrier and resulted in better and predictable dissolution profiles.