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Abstract

Comparison Between Hydroxypropyl b-Cyclodextrin And Polyvinylpyrrolidone As Carriers For Carbamazepine Solid Despersions

Author(s): Vaishali Londhe, Mangal Nagarsenker

Solid dispersions of carbamazepine were prepared in order to improve its aqueous solubility by simple kneading procedure. Hydroxypropyl b-cyclodextrin and polyvinyl pyrrolidone were used as carriers. Solid dispersions were stored at room temperature in a dessicator over anhydrous calcium chloride for one month. The changes in dispersions during storage were assessed by X-ray diffraction studies and dissolution studies. It was concluded from this study that hydroxypropyl b-cyclodextrin, as a carrier, reduced crystalline nature of carbamazepine in solid dispersions to a greater extent than polyvinyl pyrrolidone as a carrier and resulted in better and predictable dissolution profiles.