All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Abstract
Comparison Of Diffusion And Permeability Of Selected Drugs : Effect Of Physicochemical Properties And Permeation Enhancers
Author(s): Sarasija Suresh, H. P Joshi
An attempt was made to compare and assess the permeability characteristics of selected drug molecules by varying lipophilicity and molecular weight using in vitro diffusion assembly and everted small intestinal sac model. Apparent permeability coefficient, flux, permeability coefficient and enhancement ratio of selected drug molecules through both the models were compared. The permeation data was compared with physicochemical properties including solubility parameter of drug molecules. In vitro data was found to be higher than the data obtained from everted sac model. Permeation of drugs through everted sac model was significantly enhanced by incorporation of sodium taurocholate (1%), which could be correlated with in vitro diffusion data.
new hd xxx videos, english sex video, japanese porn, telugu porn stars, hd hindi xxx video, kannada sex
PDF
