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Abstract

Computer Aided Analysis Of In Vitro Release Data Of A Sustained Release Product

Author(s): B. B Barik, B. K Gupta, Manjushri Pal

Isoniazid microcapsules were prepared using ethylcellulose as coating polymer and by phase-separation and coacervation process involving non-solvent addition. In vitro dissolution was done and the release data were analysed by computer for different kinetic equations e.g. zero order, first order, square root, cube root, binomial equation, weibull equation and logarithmic liglstic plots. Statistical parameters such as sum of deviation, sum of square deviation and standard error of estimates in each case were determined and compared.