Controlled Release Pellets Of Isoxsuprine Hydrochloride
A multiparticulate controlled release formulation of Isoxsuprine HCI was developed which comprised of spherical pellets coated with a rate controlling membrane. The pellets were prepared using Extrusion-Spheronization technology. Studies were undertaken to design a prototype formula for the drug cores which is amenable to spheronization. The pellets were coated using nonaqueous solutions of polmers such as ethyl cellulose and Eudragits by pan coating technique. The successful formulations were then evaluated for their pellet characteristics, in vitro release profiles and stability.