Cytotoxic action of ixora javanica leaves.
Amala Cancer Research Centre, Amala Nagar, Trichur-680 553, (Kerala),
S C Nair Amala Cancer Research Centre, Amala Nagar, Trichur-680 553, (Kerala)
The cytotoxic principles of Ixora javanica was separated from 50 percent ethanol extract by ethyl acetate and purified by paper chromatography using butanol acetic acid water (6:1:2). The active fraction was cytotoxic on DLA EAC and S-180 cells at a concentration of 30;90 and 20 gms respectively. The mechanism of action is probably at the DNA level.