Cytotoxic and antitumour studies of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its transition Metal Complexes
Department of Chemistry, University of Calicut, Malappuram-673 635, India
K K Aravindakshan Department of Chemistry, University of Calicut, Malappuram-673 635 India E-mail: [email protected]
Cytotoxic activities of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone (L2H) and its seven different metal complexes were studied. Of these, IC50value of the copper complex was found to be 46 μg/ml. Antitumour studies of this copper complex was carried out using Daltons Lymphoma Ascites cell-induced solid tumour model and Ehrlich's Ascites Carcinoma cell-induced ascites tumour model. Administration of the copper complex at different concentrations (10, 5 and 1 mg/kg b. wt) inhibited the solid tumour development in mice and increased the mean survival rate and the life span of Ascites tumour bearing mice in a concentration dependent manner.