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Abstract

Design And Characterization Of Mucoadhesive Buccal Patches Of Dicofenac Sodium

Author(s): L Panigrahi, Snigdha Pattnaik, S. K Ghosal

Mucoadhesive patches for delivery of diclofenac sodium were prepared using polyvinyl alcohol, hydroxyethyl cellulose and chitosan. Swelling and bioadhesive characteristics were determined for both plain and medicated patches. The results showed an increase in radial swelling after addition of diclofenac sodium to the plain formulation. A decrease in residual time observed for polyvinyl alcohol and chitosan containing formulae. High drug release was obtained from polyvinyl alcohol compared to the hydroxyethyl cellulose. Physical characteristics of the studied patches showed promising with good bioadhesion.