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Abstract

Design And Evaluation Of Sustained Release Suppositories Of Nimesulide

Author(s): N Jawahar, S Jayapraksh, N. S Maria Gerald Rajan, M Nagarajan, D Dhachina Moorthi, S Jubie, R Manivannan

Nimesulide sustained release suppositories were formulated by 23 full factorial design using polymers such as agar, polyethylene glycol-6000 and sodium carboxymethylcellulose. The unconventional non-melting, non-disintegrating suppositories were prepared using fusion method and their in vitro release kinetics were studied. Physical characteristics such as dimensions, homogeneity, crushing strenyth and drug content uniformity were evaluated. Among the various formulations, formulation (N3) with agar (6%), polyethylene glycol-6000 (4%) and sodium carboxymethylcellulose (1.5%) showed maximum drug release (93.69%) by concentration independent manner.