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Abstract

Design And Evaluation Of Timolo Maleate Ocuserts

Author(s): A. S Abhilash, S Jayaprakash, M Nagarajan, D Dhachinamoorthi

Timolol maleate ocuserts were prepared using different polymers such as hydroxypropylmethylcellulose, ethyl cellulose, Eudragit RL100 and Eudragit RS100 at various concentrations. The in vitro release of the drug from the formulations was studied using commercial semi permeable membrane. The physicochemical parameters of ocuserts were evaluated. A zero order release formulation I (drug reservoir with 1.25% hydroxypropylmethylcellulose and 1.25% ethyl cellulose and 2% hydroxypropylmethylcellulose as rate controlling membrane) was subjected to in vivo studies. The expected zero order release for one day was observed in formulation I (drug reservoir with 1.25% hydroxypropylmethylcellulose and 1.25% ethyl cellulose and 2% hydroxypropylmethylcellulose as rate controlling membrane).