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Abstract
Determination and validation of zonisamide and its four related substances by HPLC and UV-spectrophotometry
Author(s): Maryam Hosseini1, E Alipour2, Arezou Farokhsir3
1 Young researchers club, Islamic Azad University, North Tehran branch, Tehran, Iran 2 Faculty of Chemistry, Islamic Azad University, North Tehran branch, Tehran, Iran 3 Kimia Darou e Gharb Pharmaceutical Company, Shahid Salimi Industrial Site, Tabriz, Iran
Correspondence Address:
Maryam Hosseini Young researchers club, Islamic Azad University, North Tehran branch, Tehran Iran E-mail: mhosseini87@gmail.com
1 Young researchers club, Islamic Azad University, North Tehran branch, Tehran, Iran 2 Faculty of Chemistry, Islamic Azad University, North Tehran branch, Tehran, Iran 3 Kimia Darou e Gharb Pharmaceutical Company, Shahid Salimi Industrial Site, Tabriz, Iran
Correspondence Address:
Maryam Hosseini Young researchers club, Islamic Azad University, North Tehran branch, Tehran Iran E-mail: mhosseini87@gmail.com
A selective and sensitive liquid chromatographic method has been developed for simultaneous determination of zonisamide and its four related substances in pharmaceutical dosage forms. The assay involved an isocratic elution in perfectsil Target C18 column using a mobile phase composition of disodium hydrogen phosphate buffer, acetonitrile and methanol (650:150:200 v/v, pH adjusted to 3±0.05) with flow rate 1.2 ml/min and analyte monitored at 240 nm. Also a simple and precise spectrophotometric method was developed for dissolution studies. These proposed methods are sensitive, accurate, reproducible and useful for the routine determination of zonisamide in pharmacy.
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