All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Determination of 1,7,7-trimethyl-bicyclo(2,2,1)heptan-2-one in a cream pharmaceutical formulation by reversed-phase liquid chromatography

Author(s): GA Shabir, TK Bradshaw
Oxford Brookes University, School of Life Sciences, Oxford, OX3 0BP, United Kingdom

Correspondence Address:
G A Shabir Oxford Brookes University, School of Life Sciences, Oxford, OX3 0BP United Kingdom E-mail: [email protected]


A reversed-phase liquid chromatographic method for the determination of 1,7,7-trimethyl-bicyclo(2,2,1)heptan-2-one in a cream formulation is developed and validated. The separation was achieved using an isocratic mobile phase, on a Lichrosorb C8 column. The calibration curve is linear (r 2 = 0.9999) from 25-175% of the analytical concentration of 1.0 mg/ml. The mean percent standard deviation values for intra-day and inter-day precision studies were <1%. The recovery ranges 99.80-100.06% from a cream formulation. The method can be used reliably in quality control for the analysis of bulk cream samples and final product release.



Share this