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Abstract

Determination of pyrimethamine in drug preparations by fluorimetry.

Author(s): P Parimoo
Dept. of Pharmacy, B.I.T.S., Pilani,

Correspondence Address:
P Parimoo Dept. of Pharmacy, B.I.T.S., Pilani

A simple and sensitive fluorimetric procedure is described for the analysis of pyrimethamine in dosage forms depending on its strong fluorescence in 1 normal sulphuric acid (lamda excitation = 321 nm, (lamda emission = 425 nm) with a detection limit of 1 mug/ml. The addition of molecules of sulfodoxine cause a quenching in the region of excitation and emission of the former compound.