Determination of pyrimethamine in drug preparations by fluorimetry.
Dept. of Pharmacy, B.I.T.S., Pilani,
P Parimoo Dept. of Pharmacy, B.I.T.S., Pilani
A simple and sensitive fluorimetric procedure is described for the analysis of pyrimethamine in dosage forms depending on its strong fluorescence in 1 normal sulphuric acid (lamda excitation = 321 nm, (lamda emission = 425 nm) with a detection limit of 1 mug/ml. The addition of molecules of sulfodoxine cause a quenching in the region of excitation and emission of the former compound.