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Abstract

Determination of pyrimethamine with n-chlorosuccinimide in acidic medium.

Author(s): HC Dwivedi, IC Shukla
Dept. of Chemistry, University of Allahabad, Allahabad,

Correspondence Address:
H C Dwivedi Dept. of Chemistry, University of Allahabad, Allahabad

A new method for the milligram determination of pyrimethamine in pure form and in pharamaceutical preparations has been developed within the accuracy of +/- 1 percent error. Drug samples (1-5 mg) are reacted with excess of N-chlorosuccinimide (NCS) in acidid medium at room temprature (25 degree) for about 15 min. The excess of the reagent is determined iodometrically.