Determination of pyrimethamine with n-chlorosuccinimide in acidic medium.
Dept. of Chemistry, University of Allahabad, Allahabad,
H C Dwivedi Dept. of Chemistry, University of Allahabad, Allahabad
A new method for the milligram determination of pyrimethamine in pure form and in pharamaceutical preparations has been developed within the accuracy of +/- 1 percent error. Drug samples (1-5 mg) are reacted with excess of N-chlorosuccinimide (NCS) in acidid medium at room temprature (25 degree) for about 15 min. The excess of the reagent is determined iodometrically.