Abstract

Determination of Triethylamine, Pyridine and Dimethyl formamide content in Telmisartan by Headspace Gas chromatography using Flame Ionization Detector

Author(s): J. Gopalakrishnan* and S. Asha Devi1
Piramal Enterprises Limited, Analytical Development Laboratory, 1, Nirlon complex, Off western expressway, Goregaon-E, Mumbai-400 101, 1School of Biosciences and Technology, VIT University, Vellore-632 014, India

Correspondence Address:
Piramal Enterprises Limited, Analytical Development Laboratory, 1, Nirlon complex, Off western expressway, Goregaon-E, Mumbai-400 101, India E-mail: [email protected]


Triethylamine, pyridine and dimethyl formamide are used as solvents in the synthesis of telmisartan. A simple, accurate and precise analytical method for determination of triethylamine, pyridine and dimethyl formamide in telmisartan was developed on headspace gas chromatography. The sample was dissolved in N-methyl pyrrolidone. Headspace vials of standard size and volume of 20 ml capacity were used for the study. The vials were incubated at 100°, for 20 min. Injection volume of headspace in to the gas chromatograph was 1 ml. The syringe temperature was maintained at 110°. The injector and detector temperature were 200° and 250°, respectively. Nitrogen gas was used as carrier gas with flow rate of 1 ml/min. Split ratio was 1:10. DB624 column with 30 m × 0.32 mm i.d., 1.8 µm film thickness was used. Column oven temperature was maintained at 40° for 15 min, followed by an increase up to 240° with the rate of 30°/min. The final temperature of the column with 240° was maintained for 5 min. This analytical method was validated with respect to precision, linearity, recovery, limit of detection and limit of quantification.



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