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Abstract

Development And Evaluation Of Ethylcellulose Coated Controlled Release Pellets

Author(s): A. K Handa, A. V Kerudi, H. L Bhalla

Pellets of isosorbide-5-mononitrate (ISMN) and carbamazepine (CBZ), were prepared by suspension layering and powder layering techniques, respectively. The different processing conditions were optimized. The drug loaded pellets were coated using ethylcellulose as release retardant. Different coat weights were applied and pellets were subjected to in vitro release studies. Formulations showing similar in vitro release profile to the innovator's product under different conditions of pH and agitation were selected for accelerated stability studies. These were found to be stable under different conditions of storage, for a period of 6 months.