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Abstract

Development and validation of spectrophotometric methods for simultaneous estimation of tramadol hydrochloride and chlorzoxazone in tablet dosage form

Author(s): Manisha Puranik, A Hirudkar, SJ Wadher, PG Yeole
Department of Quality Assurance, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442 001, India

Correspondence Address:
Manisha Puranik Department of Quality Assurance, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442 001 India E-mail: [email protected]


Two simple, accurate, and precise methods for simultaneous estimation of tramadol hydrochloride and chlorzoxazone in combined dosage form have been described. The first method employs formation and solving of simultaneous equations using 272.20 and 248.30 nm as two analytical wavelengths. The second method is absorption ratio method, which uses 272.20 and 257.50 nm as two analytical wavelengths. Both the methods allow the simultaneous determination of tramadol hydrochloride and chlorzoxazone in concentration ranges employed for this purpose with the standard deviation of <1.0% in the assay of tablet.



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