Development of mesophasic microreservoir-based transdermal drug delivery system of propranolol
Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Barela, Jabalpur-483 001, India
L K Omray Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Barela, Jabalpur-483 001 India E-mail: [email protected]
The mesophasic microreservoir comprises lyotrophic liquid crystals. The liquid crystals were prepared of Brij-35, cetosteryl alcohol and propranolol and evaluated for parameters viz. anisotropy, size and size distribution and drug entrapment efficiency. Subsequent to this liquid crystals based transdermal drug delivery system (TDS) was prepared by incorporating liquid crystals in previously prepared matrix based transdermal patch and evaluated for stability studies like temperature, humidity and aging. The system was also studied for tensile strength, moisture content, water vapor transmission, drug content, anisotropy and In vitro drug release studies.