Development Of Transdermal Patches Of Verapamil Hydrochloride Using Sodium Carboxymethyl Guar As A Monolithic Polymeric Matrix And Their Invitro Release Studies
An attempt has been made to develop Transdermal patches of Verapamil HCI by using Sodium Carboxymethyl Guar as Polymer matrix, Propylene glycol as the plasticiser and Alupoly foil as the backing membrane. A comparison of various polymers and plasticisers were also made. In vitro release studies through mouse skin have shown that Sodium Carboxymethyl Guar as a suitable polymer. The primary skin irritatancy tests have shown that the transdermal patches are non irritant.