Direct Spectrophotometric Analysis Of Glipizide And Phenformin Hydrochloride In Pharmaceutical Dosage Forms
Solvent extraction methods followed by spectrophotometric determination of glipizide and phenformin hydrochloride are proposed here. These method are based on the coloured dye-complex formation between acridine yellow and glipizide (AY-G) and brom cresol green and phenformin hydrochloride (BCG-PH) and their extraction by chloroform. The coloured dye complex of AY-G and BCG-PH in chloroform reveal absorption maximum at 426 nm and 415 nm respectively. The System conforms to Beer's law in the range 15 to 100 Âµg/ml for glipizide and 4 to 24 Âµg/ml for phenformin hydrochloride. Glipizide and phenformin hydrochloride were determined in pure form first and then in oral hypoglycaemic tablets by proposed methods.