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Abstract

Direct UV Spectrophotometric Estimation Of ?-Areether

Author(s): Divya Jain, D Bhadra, S Bhadra, N. K Jain

A simple rapid, precise, accurate and highly specific spectrophotometric method has been developed for the determination of β-arteether in its pharmaceutical dosage forms. Arteether is a newer antimalarial derivative of artemisinin. Arteether has no UV absorption above 220 nm because of the absence of any chromophore group in its molecule. Therefore, it has to be degraded with 5M HCI, which produces chromophore groups that can absorb at 254 nm. Beer-Lambert law is followed in the concentration range of 5-50 μg/ml. The accuracy and reproducibility of the proposed method was statistically validated by variation studies.