Does ethnic variability exist in the systemic exposures of oatp1a2 substrates?fexofenadine in taiwanese?
1Protech Pharmaservices Corporation, 11F, No.3, Park St., Nangang District, Taipei City 11503, Taiwan, R.O.C, Taiwan 2College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, , R.O.C, Taiwan
K Y Hsu College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan, R.O.C Taiwan E-mail: [email protected]
The aim of this study was to investigate differences in organic anion transporting polypeptide 1A2 activity among the Taiwanese population via an analysis of 3 pharmacokinetic studies completed in a total of 103 healthy male Taiwanese subjects. The pharmacokinetics of fexofenadine was measured as an indicator of organic anion transporting polypeptide 1A2 activity. Using the Kolmogorov-Smirnov test and quantile plots, the frequency distributions of area under the concentration-time curve and concentration were shown to be tri-modal and to represent 3 pharmacokinetic phenotypes. In a comparison with published data, the mean area under the concentration-time curve of fexofenadine in the Taiwanese subjects was similar to that in American, German, and Indian subjects, but significantly different from that in some Asian populations, including Korean and Japanese ethnic groups. These results suggested that Taiwanese subjects showed genetic variation in fexofenadine pharmacokinetics that was associated with differences in organic anion transporting polypeptide 1A2 activity.