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Abstract

Drug interaction-I : interaction between sedatives and cns stimulants.

Author(s): MK Bagi, HK Kakrani, GA Kalyani
Dept. of Pharmacology J. N. Medical College, Belgaum 590 010,

Correspondence Address:
M K Bagi Dept. of Pharmacology J. N. Medical College, Belgaum 590 010

The interaction of pentobarbitone and diazepam with ephedrine and caffeine was evaluated. Ephedrine was found to potentiate and caffeine reduced sleep time of both the C.N.S. depressants. Indomethacin reversed the effects of ephedrine. Reserpine potentiated the effects of pentobarbitone and diazepam but reserpine pre-treatment reduced the effects of ephedrine which may probably be due to non-availability of catecholamines-stores. Phenoxybenzamine significantly counteracted the action of hypnotics and propranolol potentiated.