Dual control over release of a water soluble drug from compressed tablets.
Faculty of Pharmacy, University of Manitoba, Winnipeg, R3T 2N2, Canada
D Kaul Faculty of Pharmacy, University of Manitoba, Winnipeg, R3T 2N2, Canada
This paper describes the concept of dual control over the release of a water soluble drug. It was hypothesized that the release of a water soluble drug. It was hypothesized that the release of a drug from a tablet containing only a sustaining matrix or only a rate controlling membrane would be different from a tablet containing both the matrix and the membrane. Agents used in the matrix included Eudrigits (RSPM and RLPM) and various grades of Methocel. The drug was incorporated into the matrix at various weight ratios by the coprecipitation method. Ethylcellulose dispersion (Aquacoato )was used as the model coating agent. The release profiles showed the importance of the type and concentration of the polymer in the matrix. The results also indicated the possibility of obtaining a near zero-order release by this mechanism. key words: Sustained release, Dual-control, Coprecipitation.